1,4-BDMT, Benzylic thiol scavenger used in TFA cleavages of peptide resins.
CAS: 105-09-9
Synonym: 1,4-Benzenedimethanethiol
Properties
Purity
≥98.0%
Molecular Formula
C6H4(CH2SH)2
Molecular Weight
170.30 [gr/mol]
Appearance
White to off-white crystalline powder
Storage Conditions
Store in a cool place
Applications
- 1,4 -BDMT -scavenger in TFA cleavages of peptide resins.Combining the high reactivity of aliphatic thiols with the UV visibility of aromatic compounds.
- More effective scavenger *
- Resulting in higher purity of peptides**
- Efficient in minimizing formation of peptide-t-Bu adducts
- Efficient in minimizing sulfonylation of the peptide
- Higher stability compared to aliphatic thiol scavengers***
- Suitable solubility
- Easily UV detectable
- Commercially available in bulk quantities
* Chemical yields, compared to DTT, ETT, DODT
** HPLC purity, compared to DTT, DODT
*** Chemical stability in TFA/TIS/H2O, compared to DTT, DODT
Studies
- Benzylthiols as scavengers in TFA cleavages of peptide resins
Jan Pawlas, Thomas Svensson and Jon H. Rasmussen, PolyPeptide Group, Poster at 26th APS.
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