The convenient activator for RNA synthesis.
CAS: 89797-68-2
Synonym: 5-(Ethylthio)-1H-tetrazole
Properties
Purity
≥99.0%
Molecular Formula
C3H6N4S
Molecular Weight
130.17 [gr/mol]
Appearance
White to off-white crystalline powder
Storage Conditions
Store in a cool and dry place
Applications
- ETT is much more soluble than 1H-tetrazole – the first activator for DNA synthesis.
- Effective racemization suppressor in peptide synthesis. It can be used together with T-BEC or DIC.
Studies
- Large Scale Synthesis of Oligonucleotides via Phosphoramidite Nucleosides and a High-loaded Polystyrene Support
P. Wright, D. Lloyd, W. Rapp, and A. Anrus Tetrahedron let., 1993, 34, 21, 3373-3376. - Synthesis and Macrodomain Binding of Mono-ADP-Ribosylated Peptides
H. A. V. Kistemaker, A. Pio Nardozza, H. S. Overkleeft, G. A. van der Marel, A. G. Ladurner, and D. V. Filippov
Angew. Chem. Int. Ed. 2016, 55, 10634–10638.
Read Article - Application of a new green protocol in solid-phase peptide synthesis: identification of a new green solvent mixture compatible with TBEC/ETT. Vivenzio, G., Scala, M. C., Auriemma, G., Sardo, C., Campiglia, P., & Sala, M. (2024). Green Chemistry Letters and Reviews, 17(1). https://doi.org/10.1080/17518253.2024.2404234