HOAt is a classic and best-on-the-market additive for reducing epimerization during the coupling reaction. Luxembourg Bio Technologies is selling HOAt in DMSO solution to ensure ease of use and safe shipping.
CAS:39968-33-7
Synonym: 1-Hydroxy-7-azabenzotriazole in Dimethyl sulfoxide
Properties
Purity
Molecular Formula
C5H4N4O
Molecular Weight
Appearance
Yellowish liquid
Storage Conditions
Store in a cool and dry place (2-8oC)
Applications
- Additive to coupling reactions as a racemization suppressor.
- Used in both solid-phase and solution-phase peptide synthesis.
- Ready-for-use solution of HOAt in DMSO.
- 15% or 20% solution of HOAt in DMSO produced to customer’s specifications.
- Easy to ship, store, and handle.
Studies
- Louis A. Carpino, Ayman El-Faham, Fernando Albericio,
Racemization studies during solid-phase peptide synthesis using azabenzotriazole-based coupling reagents,
Tetrahedron Letters, Volume 35, Issue 15, 1994,Pages 2279-2282,
https://doi.org/10.1016/0040-4039(94)85198-0 - Louis A Carpino, Ayman El-Faham,
The diisopropylcarbodiimide/ 1-hydroxy-7-azabenzotriazole system: Segment coupling and stepwise peptide assembly,
Tetrahedron, Volume 55, Issue 22, 1999, Pages 6813-6830,
https://doi.org/10.1016/S0040-4020(99)00344-0.